Micropunch grafting is a surgical technique in which very small pieces of normal skin are taken and transplanted into the vitiligo area; the transplanted melanocytes then spread to the surrounding skin, allowing pigment to gradually return.
Conventional punch grafting required harvesting and transplanting relatively large skin pieces one by one, which was time-consuming and could result in a bumpy, "cobblestone appearance" at the graft site.
To address these limitations, a motor-driven 0.8 mm micropunch grafting technique was developed. In a study analyzing 230 cases of stable, treatment-resistant vitiligo, approximately 78.7% of lesions showed more than 75% pigment recovery, and cobblestone appearance was observed in 18.3% of cases.
Later, a technique using a 0.5 mm punch, called the Skin Seeding Technique (SST), was also developed. This method allows transplantation without having to align the epidermal and dermal orientation of each small skin piece, simplifying the procedure. Studies using the 0.5 mm micropunch reported treatment success in 72–76% of cases, with cobblestone appearance observed in only 2–4%.
| Category | Conventional punch grafting | Micropunch grafting |
|---|---|---|
| Punch size | Relatively large | 0.8 mm or 0.5 mm |
| Procedure | Harvesting and transplanting skin pieces one by one | Rapid harvesting and transplantation of small skin pieces |
| Main limitations | Surgery time, cobblestone appearance | Developed to reduce drawbacks of the conventional method |
| 0.5mm SST | Not applicable | Can be transplanted without much concern for graft orientation |
