Vitiligo

Is micropunch grafting for vitiligo covered by health insurance?

Micropunch grafting for vitiligo has been eligible for health insurance coverage since December 1, 2019. Grafting using a micropunch is recognized as 'full-thickness skin grafting' under health insurance. However, not all patients with vitiligo are candidates for surgery; the decision should be made by considering the location of the lesions, the stability of the vitiligo, and the response to previous treatments.

How is micropunch grafting different from conventional punch grafting?

Micropunch grafting is a surgical technique in which very small pieces of normal skin are taken and transplanted into the vitiligo area; the transplanted melanocytes then spread to the surrounding skin, allowing pigment to gradually return.

Conventional punch grafting required harvesting and transplanting relatively large skin pieces one by one, which was time-consuming and could result in a bumpy, "cobblestone appearance" at the graft site.

To address these limitations, a motor-driven 0.8 mm micropunch grafting technique was developed. In a study analyzing 230 cases of stable, treatment-resistant vitiligo, approximately 78.7% of lesions showed more than 75% pigment recovery, and cobblestone appearance was observed in 18.3% of cases.

Later, a technique using a 0.5 mm punch, called the Skin Seeding Technique (SST), was also developed. This method allows transplantation without having to align the epidermal and dermal orientation of each small skin piece, simplifying the procedure. Studies using the 0.5 mm micropunch reported treatment success in 72–76% of cases, with cobblestone appearance observed in only 2–4%.

CategoryConventional punch graftingMicropunch grafting
Punch sizeRelatively large0.8 mm or 0.5 mm
ProcedureHarvesting and transplanting skin pieces one by oneRapid harvesting and transplantation of small skin pieces
Main limitationsSurgery time, cobblestone appearanceDeveloped to reduce drawbacks of the conventional method
0.5mm SSTNot applicableCan be transplanted without much concern for graft orientation

When did health insurance coverage for micropunch grafting begin?

Since December 1, 2019.

Through a revision of the Ministry of Health and Welfare notice, skin grafting using a micro punch was explicitly included under the "full-thickness skin graft" item in the health insurance system. According to the Health Insurance Review and Assessment Service, criteria were established to recognize medical care benefits for micropunch full-thickness skin grafting performed for vitiligo.

At the same time, autologous epidermal grafting using suction blisters was also codified in the health insurance system as "partial-thickness skin graft."

In the past, there was no clear reimbursement basis for micropunch grafting; the 2019 revision allowed surgical treatment for vitiligo to be more clearly recognized within the health insurance system.


Can all areas of vitiligo receive health insurance coverage?

Not necessarily. For health insurance coverage of vitiligo treatment, the location of the lesions must also be considered.

According to the Health Insurance Review and Assessment Service's reimbursement principles for vitiligo treatment, coverage is recognized for treatment of exposed areas that can affect social life, such as the face, neck, hands, arms, and areas below the knees, as well as lesions connected to these areas.

Therefore, simply having a diagnosis of vitiligo does not mean that health insurance will apply equally to treatment of all areas.

Checklist itemMeaning
Vitiligo diagnosisBasic requirement for micropunch grafting reimbursement
Lesion locationCheck whether the area is exposed, such as the face, neck, arms, or below the knees
Treatment scopeInsurance calculation may vary depending on the actual surgical site and area
Surgical methodMicropunch is calculated as full-thickness skin graft

If it is covered by insurance, should everyone choose micropunch grafting?

Whether health insurance applies and whether the vitiligo is suitable for surgery are separate issues.

Micropunch grafting is generally considered for stable vitiligo where pigment recovery has been insufficient despite phototherapy or medication, and where no new lesions have appeared or existing lesions have not enlarged for a certain period.

In particular, if vitiligo continues to progress after surgery, the transplanted pigment may not remain stable, so it is important to assess disease activity before surgery.

In fact, a study on 0.8 mm micropunch grafting found that vitiligo that had remained stable for 12 months or longer was a factor associated with better treatment outcomes. A comprehensive analysis of multiple vitiligo surgery studies also reported that patient age, vitiligo type, and lesion location may influence treatment results.

Therefore, the decision to undergo surgery should not be based solely on lesion size but should consider the following factors together:

- Whether new vitiligo lesions have appeared recently

- Whether existing lesions are expanding

- How well the lesions have responded to phototherapy or medication

- Which areas are affected, such as the face, neck, or hands

- The type and extent of vitiligo


Is excimer laser treatment still needed after micropunch grafting?

It may be necessary. Micropunch grafting is not simply a skin transplant that completes treatment; the process by which the transplanted melanocytes spread to the surrounding vitiligo skin and restore pigment is crucial.

For this reason, phototherapy such as excimer laser is often used after surgery to aid pigment recovery. In the 0.8 mm micropunch grafting study, treatment outcomes were evaluated after combining excimer therapy following surgery.

Additionally, for health insurance claims, medical records and surgical records are needed to confirm the treatment area and surgical scope.

Ultimately, what matters in vitiligo surgery is not simply checking whether the surgery is covered by health insurance. To expect more stable pigment recovery, you should also plan whether the vitiligo is stable enough for surgery, which areas will be treated, and what follow-up treatment will be continued after surgery.


References

  • Bae JM, Lee JH, Kwon HS, et al. Motorized 0.8-mm micropunch grafting for refractory vitiligo: A retrospective study of 230 cases. J Am Acad Dermatol. 2018;79(4):720-727.e1.

  • Kim DS, Ju HJ, Lee HN, et al. Skin seeding technique with 0.5-mm micropunch grafting for vitiligo irrespective of the epidermal-dermal orientation: Animal and clinical studies. J Dermatol. 2020;47(7):749-754.

  • Ju HJ, Bae JM, Lee RW, et al. Surgical Interventions for Patients With Vitiligo: A Systematic Review and Meta-analysis. JAMA Dermatol. 2021.

  • Health Insurance Review and Assessment Service. Ministry of Health and Welfare Notice No. 2019-247, Partial Amendment of the 'Health Insurance Benefit and Non-Benefit List and Relative Value Scale'.

  • Health Insurance Review and Assessment Service. Benefit Criteria for 'Whether Treatment for Vitiligo or Leukoderma is Covered'.

Jung Min Bae

Dermatologist · Gangnam Branch

With sincere care and continuous research, I will be a reliable companion for vitiligo patients.