It is believed that the body's immune system mistakenly attacks pigment cells. This is called an "autoimmune" response.
Normally, the immune system is a defense system that attacks harmful external agents. However, in vitiligo, the immune system mistakenly attacks "your own pigment cells." As a result, pigment cells decrease or disappear, and the affected area turns white. This autoimmune mechanism is currently considered the most likely cause.
However, there is not just one cause. It is understood that multiple factors, including genetic predisposition, oxidative stress, and neurological factors, act together. In other words, in people with a genetic predisposition, an immune response combined with environmental factors leads to the loss of pigment cells.
