For sensitive and thin skin, the PN (polynucleotide) series is generally well-tolerated. The main ingredient of REJURAN®, polynucleotide, is a DNA fragment purified from salmon, and is known to have high biocompatibility due to its homology with human DNA. It is not a dermal filler that adds volume, but rather stimulates fibroblasts to aid the skin's own regeneration and collagen synthesis, making it suitable for improving texture and restoring the barrier in sensitive skin.
However, "safe" does not mean "no reaction." Immediately after injection, mild swelling, redness, or tingling may occur, and these usually subside within a few days. For more sensitive skin, starting with a conservative concentration and injection volume and monitoring the reaction can help reduce individual variation.




