Re2O® is said to contain 'human-derived' ingredients — is it safe?

The tissue used in Re2O® undergoes an acellularization process that removes cells to minimize immune rejection reactions. Human tissue-derived materials have been used for a long time in various medical fields and are known to be supplied according to strict tissue safety management standards.

How painful is the Re2O® treatment?

Re2O® is a treatment that injects fine particles into the dermal layer, and you may feel a tingling sensation during the injection. We use anesthetic cream before the treatment to reduce discomfort. However, pain perception varies significantly between individuals, so please let us know if you feel uncomfortable during the procedure.

How much swelling or downtime is there after Re2O® treatment?

Immediately after Re2O® treatment, fine swelling or faint bruising may temporarily appear at the injection sites. Human tissue-derived ingredients are known to have high biocompatibility, so recovery is often relatively uneventful. If you have an important schedule, please allow about 2 weeks of buffer time when scheduling the treatment.

When will I feel the effects of Re2O® and how long do they last?

Re2O® requires time for the ingredients to settle, so rather than immediately after the treatment, you will gradually feel your skin becoming firmer. On average, many people experience the greatest effect about 2 weeks after the treatment, and since it supplies actual dermal components, once settled, the effect tends to be relatively stable. The duration of the effect depends on your skin's aging condition and care habits.

Is there no possibility of side effects like nodules with Re2O®?

Re2O® is known to have relatively fewer foreign body reactions compared to synthetic materials because it is based on human tissue components. However, depending on the injection volume and individual response, nodules or clumping may rarely occur, so it is important to inject it evenly and dispersed. If a firm area persists for a long time, please contact us.

Restoring the skin’s natural density Re2O®

A skin booster that directly replenishes the structural components of the dermis, restoring density and thickness while also addressing pores and fine lines.

Treatment Time: About 30–50 minutes (including anesthesia)
Anesthesia: Performed after topical anesthesia
Recovery Time: Bruising: 2–7 days
Recommended Interval: Every 4–12 weeks depending on skin condition

Anti-Aging Skin Booster

re2o

What is Re2O®?

A Skin Booster that injects human-derived extracellular matrix (ECM) components into the dermal layer to help restore the skin's own structure. It is used to manage dermal density, skin texture, and elasticity.

01 Skin Texture
02 Firmness
03 Elasticity

Mechanism

How Re2O® works

Re2O is an ECM (extracellular matrix) booster based on acellular allogenic dermis, which directly supplies the dermal layer with skin-building substances such as collagen, elastin, and hyaluronic acid. It fills in the components needed by the thinned dermal structure, providing a foundation for the skin to recover on its own. Through this, improvements in wrinkles, pores, and skin regeneration can be expected, and with repeated treatments, dermal density gradually fills in.

Aged, unhealthy skin
ECM components extracted from healthy skin
Skin restored to health after ECM component insertion

Effects

Effects of Re2O®

Elastic density filling from within
Firmer skin elasticity
Clear and transparent complexion
Strengthening the healthy skin barrier

Device Specifications

Manufacturer: Developed and manufactured by L&C Bio / Domestic distribution and sales rights by Humedix (Huons Group). Launched November 2024
Official Product Name: Elravie® Re2O® (lineup: Re2O® 150mg, Re2O® Fine 50mg)
Main component/Principle: Human Acellular Dermal Matrix (hADM) 150mg
Treatment depth/Layer: Dermis. Application areas — Re2O: full face, neck / Re2O Fine: under eyes, neck wrinkles
Proprietary Technologies: AlloClean® technology — L&C Bio's patented human tissue processing technology
Specifications/Capacity: 150mg × 1 syringe / box. Storage at room temperature 1–30°C

Who It's For

Feel their dermal layer has thinned and their skin lacks strength
Are concerned about deep wrinkles and sagging pores together
Have not experienced satisfactory improvement with existing Skin Boosters
Desire fundamental improvement in the skin's own structure

Adverse Effects

Side Effects and Adverse Reactions

Immediately after Re2O treatment, minor swelling or faint bruising may temporarily appear at the injection site. Bruising typically fades within 2 to 7 days.

Common Symptoms

Swelling, bruising

Rare Symptoms

Nodules, lumps, redness, persistent pain

If Symptoms Persist

If abnormal reactions such as excessive swelling, redness, or pain persist, please contact the clinic.
Other rare adverse reactions and individual risk factors will be explained in detail during your pre-treatment consultation.

FAQ

Re2O, frequently asked questions

Re2O® requires time for the components to settle, so rather than immediately after treatment, you may gradually feel your skin becoming firmer. On average, many people experience the most noticeable effect around 2 weeks after treatment. Since it supplies actual dermal components, once settled, it tends to maintain relatively stable results. The duration of effects varies depending on the individual's existing skin aging condition and care habits.

If your skin is very thin and lacks firmness, it is recommended to have an intensive care period with 2–3 sessions of Re2O® at 4-week intervals to fill the density of the thinned dermal layer, and then transition to maintenance care depending on your skin's condition. On the other hand, if the degree of skin damage is not high, the treatment interval can be extended to about 2–3 months. The more you repeat the treatment, the more solidly the rebuilding effect tends to establish itself, and the exact number of sessions is determined after a consultation based on the degree of damage.

Aftercare

Post-Treatment Care

Swelling that rarely occurs immediately after the treatment will subside within a few days, so please observe it with some patience.
On the day of the treatment, avoid strong pressure, massage, sauna, and strenuous exercise.
Keep the treated area clean and apply sunscreen generously.
If abnormal reactions such as excessive swelling, redness, or pain persist, please contact the clinic.

COMPARISON

What is the difference between REJURAN®, JUVELOOK, and Re2O®?

Material Polynucleotide (PN) 20 mg/mL PDLLA + Hyaluronic Acid Acellular Dermal Matrix (hADM) 150 mg

Origin Salmon DNA Synthetic polymer Human tissue

Target Layer Superficial dermis Upper dermis (32G 9-pin meso needle) Dermis

Specification — 50 mg vial (lyophilized) — reconstituted before use 150 mg × 1 syringe/box, room temperature 1–30 °C

Recovery Bumps, bruising 2–7 days Swelling, bumps, bruising 2–7 days Bruising 2–7 days

Recommended Interval 3–4 week intervals, 3 sessions, then maintenance 3–4 week intervals, 3 sessions, then maintenance 4–12 week intervals

Synergy

Treatments that pair well with Re2O®

HEALHOUSE’S re2o

Re2O® at Heal House is different

HEAL POINT 01

Genuine products Accurate shots Exact dosage

All five Heal House branches use only genuine products, under the same standards. This applies to tips, cartridges, and medications alike. We use the agreed number of shots and dosage as planned, and disposable supplies are never reused. We deliver the exact amount precisely where it is needed.

HEAL POINT 02

Same procedure, different design

Even with the same equipment and medication, results vary depending on who receives the treatment and how it is applied
. This is because skin type, thickness, and degree of sagging differ from person to person. A higher number of shots or larger dosage does not necessarily mean better results.
A different design leads to different outcomes.

A specialist examines the patient's skin condition and designs a customized treatment

HEAL POINT 03

We read your skin first

We recommend only what your skin truly needs at this moment.

3D Skin Analysis

We analyze your current skin condition, including elasticity, sagging, and texture.
Specialist Consultation

A dermatologist directly examines your skin and plans the treatment direction.
Customized Design

We determine the necessary treatments, areas, and dosages.
Pain Management

We prepare measures to reduce discomfort before the procedure.
Performed by a Specialist

The procedure is performed precisely while monitoring your skin's response.
Follow-up Appointment

We consistently manage changes in your skin.

HEAL POINT 04

Both consultation and treatment are performed by board-certified dermatologists

Only 2% of doctors in South Korea are board-certified dermatologists. All procedures at Heal House are performed by a dermatologist with over 1,000 cases of experience. The design, the procedure, and the responsibility all lie with the specialist you meet in the consultation room.

HEALHOUSE’S Re2O®

Heal House
Re2O® Branches

Heal House's Promise

While everyone chases the same standard of beauty,
Heal House studies your most radiant, authentic moments.

Design tailored to your facial structure

We consider the balance of your facial features and bone structure to find
the most natural line that suits your face.
Treatments we would recommend to our own family

A dermatologist with over 10 years of experience prioritizes the safest methods and performs each procedure with care.
Beauty that is most true to you

Rather than artificial change, we help you get closer to the moment when your skin was at its most radiant.

References

Columns

From equipment to post-treatment care,
columns written directly by our dermatologists

LASER

Restoring the skin’s natural density Re2O®

What is Re2O®?

How Re2O® works

Effects of Re2O®

Device Specifications

Re2O®is recommended for those who

Side Effects and Adverse Reactions

Common Symptoms

Rare Symptoms

If Symptoms Persist

Re2O, frequently asked questions

01 Re2O is said to contain 'human-derived' components — is it safe?

02 How much pain is involved in Re2O treatment?

03 How much swelling or downtime can I expect after Re2O treatment?

04 When will I feel the effects of Re2O, and how long do they last?

05 How many sessions of Re2O are typically needed?

06 Is there no possibility of side effects like nodules with Re2O®?

Post-Treatment Care

What is the difference between REJURAN®, JUVELOOK, and Re2O®?

Treatments that pair well with Re2O®

Genuine products × Accurate shots × Exact dosage

Same procedure, different design

We read your skin first

3D Skin Analysis

Specialist Consultation

Customized Design

Pain Management

Performed by a Specialist

Follow-up Appointment

Both consultation and treatment are performed by board-certified dermatologists

Gangnam Branch

Suwon Branch

Pangyo Branch

Konkuk University Branch

Daegu Branch

Design tailored to your facial structure

Treatments we would recommend to our own family

Beauty that is most true to you

References

From equipment to post-treatment care, columns written directly by our dermatologists

Genuine products Accurate shots Exact dosage

From equipment to post-treatment care,
columns written directly by our dermatologists