Relatively more caution regarding nodules is needed for regenerative boosters that induce collagen production. Types that stimulate a collagen response in the tissue, such as JUVELOOK (PDLLA+HA) and Re2O® (hADM human-derived collagen), have the potential to clump locally if the material does not spread evenly. In contrast, HA-based types focused on hydration (SKINVIVE™ by JUVÉDERM®, BELOTERO® Revive) are injected in small amounts evenly into the superficial layer, so the burden of nodules is relatively lower.
In consultations, we often receive the question, "Can boosters also clump?" and the tendency differs by type. Below is a table summarizing the characteristics of each type from the perspective of nodules, for reference.
| Category | Representative Booster | General Characteristics from a Nodule Perspective |
|---|---|---|
| Hydration (HA) | SKINVIVE™ by JUVÉDERM®, BELOTERO® Revive | Superficial distribution, relatively low nodule burden |
| Regenerative (PN) | REJURAN® | High biocompatibility, relatively low risk |
| Collagen-Inducing | JUVELOOK, Re2O® | Dispersion and depth management are especially important |



