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Nasolabial Folds and Cheek Sagging in Your 40s: What Is the Priority for Procedures?

For nasolabial folds in your 40s, the cause is first divided into three types: sagging type, volume-loss type, and mixed type. For the sagging type, lifting such as Ultherapy PRIME® is considered first; for the volume-loss type, volume enhancement such as Sculptra is considered first. In practice, the mixed type, where both factors are present, is more common, and treatment is performed in stages according to the ratio.

Should I first determine whether my concern is sagging or volume loss?

Yes, it is most important to first distinguish whether the cause of nasolabial folds is the sagging type or the volume-loss type. This is because, even if they look similar on the surface, the approach differs depending on whether the problem is caused by fat sagging downward or by a loss of cheek volume creating the fold.

The sagging type occurs when the SMAS and ligaments loosen, causing fat to descend and deepen the nasolabial line; it is treated with lifting that pulls the structure upward. In contrast, the volume-loss type occurs when fat and collagen in the cheek and anterior cheekbone decrease, leading to a loss of support and a depression above the nasolabial fold; it is treated by restoring volume to reduce the step-off.

In practice, the two factors are often mixed, so a comprehensive diagnosis is important. Since this judgment requires visual inspection, palpation, and observation of facial expressions and movement, we recommend consulting a specialist rather than self-diagnosing.


Which should come first — lifting or volume?

Generally, it is better to first consider lifting to pull sagging tissue back into place, and then fill any remaining volume. This is because if you fill the depressed area first, the subsequent lifting may shift the tissue, making the filled location or amount appear misaligned.

However, this order is not absolute. If the volume deficit is pronounced and the cause of sagging is closer to volume loss, it may be more natural to first establish a foundation of volume and then finish with lifting. In other words, rather than following a formula of "lifting first," it is better to decide the order based on the individual's ratio of sagging type to volume-loss type.

TypeMain causeConsider first
Sagging typeSMAS and ligament laxity, fat moving downwardLifting first
Volume-loss typeDecrease in cheek and cheekbone fat and collagenVolume first
Mixed typeBoth factors presentStaged treatment according to ratio

How do you combine Ultherapy PRIME® and Sculptra?

Ultherapy PRIME® and Sculptra are generally combined by dividing their roles into the "axis of lifting" and the "axis of filling the foundation." Since the principles and goals of the two procedures differ, they can complement each other when sagging and volume loss coexist.

Ultherapy PRIME® is a procedure that delivers heat to the SMAS layer at approximately 4.5 mm using ultrasound energy to induce collagen remodeling and lifting. Sculptra uses PLLA to stimulate the production of autologous collagen, supplementing volume. Therefore, a common approach is to first organize the structure with Ultherapy PRIME® and then build volume in the depressed areas.

Whether to perform both procedures on the same day or sequentially with an interval is decided by considering skin response and recovery. Since the combination, order, and dosage vary greatly by individual, it is advisable to plan with a specialist.


When is thread lifting considered?

Thread lifting is an option considered together when there is moderate to severe sagging that is not adequately corrected by energy-based lifting alone, or when immediate line refinement is needed. The principle involves inserting threads to physically pull and fix sagging tissue and induce a collagen response around the threads.

However, since thread lifting involves insertion and fixation, it may involve more recovery response than ultrasound or RF lifting, and its suitability varies depending on the degree of sagging and tissue condition. If volume loss is the main cause, pulling only with threads may look unnatural, so a cause assessment must precede.

In other words, thread lifting is not a procedure that is "always necessary for severe sagging," but rather a tool whose role is determined within a combination with other procedures. We recommend discussing indications with a specialist through an in-person evaluation.


Why Shouldn't You Do Everything at Once?

The reason it is not advisable to undergo all procedures at once is that the timing of each procedure's effect differs, and if recovery responses overlap, it becomes difficult to judge and adjust the results. In particular, collagen-stimulating procedures show changes gradually over weeks to months, so it is more accurate to determine the next step after seeing the final state.

Additionally, volume should be filled after the tissue has been moved by lifting for a natural position; doing everything at the same time can increase the risk of overcorrection and asymmetry due to overlapping swelling and tissue movement. Having swelling and recovery responses all at once can also be burdensome for returning to daily life.

Therefore, for complex nasolabial folds and cheek sagging in your 40s, it is safer to proceed in stages by setting priorities rather than aiming for "completion in one session," and to adjust the next step while checking the results of each stage. We recommend designing the overall plan through a consultation with a specialist.


References

Kim Soohyung

Dermatologist · Heal House Suwon Branch

I will be your skin doctor who goes beyond healthy skin to bring positive changes to your life.