Yes, if excessive radiofrequency heat is delivered deeply into the fat layer, fat cells may shrink or become damaged, leading to volume reduction. However, this is a concern only with excessive energy or excessive overlapping treatments that deviate from the standard protocol; normal Thermage® FLX treatment is designed to target collagen in the dermal layer.
Cells damaged by radiofrequency heat may be lost gradually not only immediately after treatment but over the following weeks to months, so cheek volume loss may be noticed long after the procedure. In the end, the claim that 'Thermage® FLX always causes cheek volume loss' is an exaggeration, but it is true that it can occur with poorly designed treatments.



