Wrinkles & Contouring LSSA Ultherapy PRIME®

What is LSSA?

LSSA is a minimally invasive procedure that uses a thin ultrasound probe approximately 0.9 mm in diameter, inserted directly into the fat layer to liquefy fat, which is then drained or aspirated. It is performed under local anesthesia, taking about 15–30 minutes per area, and is primarily used to address localized fat deposits such as a double chin or jowls.

What is LSSA?

LSSA is a fat-liquefaction device that uses ultrasound energy to melt fat. It was developed in Korea and received approval from the Ministry of Food and Drug Safety in 2021. Unlike non-invasive devices that deliver energy from above the skin, LSSA uses a thin probe (about 0.9 mm in diameter for facial use, similar to a typical injection needle) inserted through a needle-sized entry point into the fat layer, without a large skin incision.

Its working principle involves three overlapping mechanisms. First, cavitation: the probe vibrating tens of thousands of times per second expands and bursts microscopic bubbles in the anesthetic fluid, and the resulting shock disrupts the membranes of surrounding fat cells. Second, mechanical action from the vibrating probe directly contacting tissue. Third, thermal action from frictional vibration.

Fat cells are relatively vulnerable to this ultrasound vibration, while nerves, blood vessels, and connective tissue are comparatively more resistant. The device is designed to target fat preferentially. However, this does not mean it does not affect anything other than fat. Since heat is also generated, controlling the power and treatment duration is important. The liquefied fat is either absorbed and eliminated naturally or aspirated through a thin cannula.


Is it effective for a double chin or jowls?

Yes, those are the areas where LSSA is primarily used. It is considered for localized fat that persists despite weight loss, such as a submental double chin, jowls drooping beside the mouth corners, and the cheeks or deep buccal fat. On the face, even a reduction of 1–2 cc per area can change the contour, so precise control is more important than removing a large amount indiscriminately.

Localized fat that does not reduce easily with weight loss often involves a concentration of fat cells in that area. In such cases, an approach that reduces the number of fat cells themselves may be helpful. The degree of change varies individually depending on the amount of fat and skin condition.

However, a poorly defined jawline may not be due to fat. If the cause is skin laxity, tension in the platysma muscle, skeletal structure, or chronic swelling, reducing fat may not produce the expected change. In fact, if skin elasticity is poor, removing fat alone may leave excess skin. In such cases, combining a lifting procedure or botulinum toxin type A to reduce muscle tension may be a better approach. Identifying the cause is the first step.


How is LSSA different from fat-dissolving injections or liposuction?

A notable difference from other methods is that it directly treats the fat layer without a large incision or sutures. The entry point is about the size of a needle hole, so the risk of scarring is relatively low. It is performed under local anesthesia, and the procedure time is short, about 15–30 minutes per area. The thin probe makes it easier to treat in layers even on the face, where nerves are dense, which is why it is considered for facial areas.

MethodApproach routeConsiderations
Fat-dissolving injectionsSyringeRequires multiple sessions; each session involves swelling and pain
Non-invasive ultrasound or radiofrequencyFrom outside the skinLow recovery burden but limited degree of change
LSSAProbe inserted through a needle holeLocal anesthesia; directly treats the fat layer; removal amount is more limited than with incision methods
Incision liposuctionCannula after incisionLarger removal amount but longer recovery period

Ultrasound-assisted liposuction has been relatively well studied academically. A survey of 660 cases performed under local anesthesia reported a complication rate of 1.36%, and a series of 261 cases with third-generation ultrasound liposuction reported 4.6%. However, these figures are from devices using the same principle, not from LSSA itself. It has also been noted that evidence for a skin-tightening effect superior to conventional liposuction is still insufficient. It is realistic to consider any tightening as a secondary expectation. The appropriate method depends on individual factors such as the amount and location of fat and skin condition.


What are the side effects of LSSA?

The most common side effects are swelling, bruising, soreness, and temporary numbness or tingling. These usually subside within a few days to two weeks, but recovery speed varies greatly among individuals.

Rare but important risks include burns due to the heat generated, uneven fat removal leading to contour irregularities or asymmetry, seroma (fluid accumulation), hematoma, infection, pigmentation or small scars at the entry points, and sensory changes from nerve irritation.

In individuals with thin skin or already reduced elasticity, fat reduction may make sagging more noticeable. The outcome of this procedure depends not only on the device's performance but also significantly on the practitioner's judgment in assessing anatomical layers and adjusting power. Since the face contains facial nerves and blood vessels, it is advisable to receive a full explanation of potential side effects before making a decision.


How painful is it? How is anesthesia used?

LSSA is performed after local anesthesia called tumescent anesthesia. Filling the fat layer with anesthetic fluid reduces pain transmission and swells the tissue, making it easier to manipulate the probe. A feature of this method is that general anesthesia is not required.

During the procedure, many describe the sensation as more of a pushing, vibrating, or heavy pressure rather than pain. However, most people feel a stinging and stretching sensation when the anesthetic fluid is injected, and pain thresholds vary individually. If you feel a hot or sharp pain during the procedure, it is important not to endure it and to inform the practitioner immediately, as this can be a signal to prevent burns.

After the procedure, you may experience a feeling of soreness similar to post-exercise muscle pain and tenderness when pressing the area for a few days. This is usually manageable with prescribed pain relievers, but if the pain gradually worsens or is accompanied by warmth or redness, there may be a possibility of infection, and you should seek medical attention.


How long is recovery, and how long do LSSA results last?

Swelling is usually limited to slight swelling around days 2 to 3 after the procedure, which gradually subsides over 1 to 2 weeks. Depending on the area, a compression band may be recommended for a few days. It generally takes about 3 months for the tissue to settle and the final contour to become apparent. Cleansing and daily activities can be resumed relatively quickly, but this varies depending on the extent of the procedure and individual differences.

The removed fat cells are known not to regenerate. However, the remaining fat cells can enlarge, causing the area to thicken again, so it is difficult to say the results are 'permanent.' Significant weight gain can also alter the outcome, so weight management after the procedure is necessary.

Some people are satisfied with a single session, while others with a larger amount of fat or a wider area may discuss additional procedures or combining different methods. We recommend consulting with a specialist to determine whether this method is suitable for you, after assessing the amount and location of fat, skin elasticity, any medications you are taking, and underlying medical conditions.


References

Hanmi Jung

Dermatologist · Gangnam Branch

I strive to be a lifelong skin doctor you can trust with all aspects of your skin, not a doctor who is forgotten after a single procedure.