Heal House Vitiligo Clinic
15 years dedicated solely to vitiligo
Thoroughness that examines even unseen areas
Warmth that lifts even the shadows of the heart
A vitiligo study began from a small question from a patient.
Among the 205 papers completed after long discussions with colleagues around the world, we introduce representative studies.
NO. 78
We confirmed that SOX10 antibodies in the blood can be a marker indicating whether vitiligo is currently spreading. These antibodies were found more often in active spreading vitiligo.
Ann Dermatol (2026)
NO. 77
Experts and patients from around the world came together to agree for the first time on common criteria for judging how severe vitiligo is and whether it is a recurrence. It considers not only the visible area but also the emotional burden.
JAMA Dermatol (2026)
NO. 76
Even for vitiligo on areas not visible to others, the psychological burden and reduced quality of life experienced by patients were by no means mild.
J Eur Acad Dermatol Venereol (2026)
NO. 75
There is a questionnaire where patients directly answer 'how much less noticeable vitiligo has become to others.' This study confirmed, using new drug clinical trial data, whether this questionnaire is a reliable tool.
Br J Dermatol (2026)
NO. 74
Vitiligo is a disease in which the body's immune system mistakenly attacks the pigment cells in the skin. It affects about 3 to 4 in 1,000 people worldwide. In recent years, new treatments that can reverse the progression of the disease have also emerged.
Nat Rev Dis Primers (2025)
NO. 73
We asked 31 vitiligo experts from 6 continents. The most common things they look at in consultations are whether the disease is improving or worsening, whether the patient is tolerating treatment well, whether it is currently spreading, and how widespread it is.
J Dermatolog Treat (2025)
NO. 72
This study examined whether a computer can determine if vitiligo is currently spreading by looking at photos.
Br J Dermatol (2025)
NO. 71
The composition of gut bacteria in patients with actively spreading vitiligo was distinctly different from that of healthy people. This suggests a possible connection between the gut and the skin.
Int J Mol Sci (2025)
NO. 70
The effect of vitiligo treatment is evaluated using the Vitiligo Area Scoring Index (VASI), which measures the extent of white patches. We confirmed that when this score improves by about 30% for the whole body and 50% for the face, patients actually feel that they have 'improved.'
JAMA Dermatol (2025)
NO. 69
It is estimated that about 3 to 4 in 1,000 people worldwide will experience vitiligo at some point in their lives. In terms of number of people, this is approximately 28.5 million. It was more common in adults.
Lancet Public Health (2024)
NO. 68
When eyelashes turn white due to vitiligo (poliosis), they can be naturally matched to the surrounding color through eyelash dyeing.
Ann Dermatol (2024)
NO. 67
Vitiligo treatment is divided into phototherapy, topical medications, oral medications, and procedures. By organizing each treatment according to how it works in the body, you can make a more informed choice. Recently, a new class of drugs called JAK inhibitors is gaining attention.
Dermatology (2024)
NO. 66
Lifespan was not shortened. Rather, the risk of death was slightly lower. In a study of about 100,000 patients in Korea, it was about 25% lower than in people without vitiligo.
J Invest Dermatol (2024)
NO. 65
Connecting vitiligo patient records scattered across multiple countries can create larger, more reliable evidence. We proposed an international roadmap called 'VIRTUAL-GLOBAL' for this purpose.
Br J Dermatol (2023)
NO. 64
We validated a method for automatically measuring the extent of facial vitiligo using a computer program (Vitil-IA) instead of the human eye. When the same photo was measured again, the error was less than 3%, showing very consistent results.
Br J Dermatol (2023)
NO. 63
Vitiligo affects not only the child but also the parents' lives. We explored the emotional burden of parents, such as worry, helplessness, and guilt, through direct interviews.
Ann Dermatol (2023)
NO. 62
This belongs to the same international consensus guideline as study no. 61. This part covers 'diagnosis and management.' It sets standards from the naming of the disease to the major steps of diagnosis, evaluation, and treatment, and emphasizes shared decision-making between doctors and patients.
J Eur Acad Dermatol Venereol (2023)
NO. 61
Vitiligo experts from around the world gathered to create international treatment guidelines. This section covers the 'treatment' part. It summarizes how to use topical medications, oral medications, and phototherapy depending on the situation.
J Eur Acad Dermatol Venereol (2023)
NO. 60
The occurrence of new white spots from cosmetic laser or IPL procedures was rare. It was reported in only 30 out of 11,300 patients (0.27%) treated by experts.
Arch Dermatol Res (2023)
NO. 59
This study examined the health of children born to mothers with vitiligo using nationwide birth data. It also checked for autoimmune, allergic, and neuropsychiatric issues.
Br J Dermatol (2023)
NO. 58
Instead of looking only at preselected diseases, we used a computer to scan all diagnosis codes. In doing so, we found 45 conditions associated with vitiligo. Unexpected links, such as melanoma and obsessive-compulsive disorder, were also revealed.
J Invest Dermatol (2023)
NO. 57
Even with vitiligo, it is not necessary to unconditionally avoid cosmetic laser or IPL procedures. However, caution is needed during the active phase of the disease. This is a consensus compiled by global experts.
J Am Acad Dermatol (2023)
NO. 56
People with vitiligo more often have accompanying autoimmune diseases such as thyroid disease, alopecia areata, and lupus. Therefore, it is necessary to examine not only the skin but the whole body together.
J Invest Dermatol (2023)
NO. 55
Vitiligo clinical trials still measure effectiveness with different yardsticks. This makes it difficult to compare them. We reviewed 174 trials to confirm this situation.
Br J Dermatol (2023)
NO. 54
This is an international clinical trial that checked whether the new oral drug LITFULO (ingredient name ritlecitinib) is effective for vitiligo. 364 people participated, and the white areas on the face noticeably decreased.
J Am Acad Dermatol (2023)
NO. 53
For vitiligo, what happens after color returns is more important. So what should you do to preserve the regained color? This is a study in which multiple hospitals worked together to find the answer through a randomized trial.
Photodermatol Photoimmunol Photomed (2022)
NO. 52
A rare case of deep burn caused by a non-hot temperature during the suction blister harvesting process used in vitiligo graft surgery has been reported.
Ann Dermatol (2022)
NO. 51
In people who took levodopa, used for Parkinson's disease and other conditions, a tendency for less vitiligo was observed in national data. This is the first study to examine the new possibility of vitiligo 'prevention'.
Br J Dermatol (2022)
NO. 50
When tretinoin cream was applied together with phototherapy, darkening of normal skin around the lesions rarely occurred. The degree of improvement in vitiligo itself remained the same.
J Dermatolog Treat (2022)
NO. 49
Using the concept of a 'fingertip unit' used when squeezing ointment as a ruler, we developed a method to accurately measure the area of facial vitiligo without special equipment.
J Am Acad Dermatol (2022)
NO. 48
There are scores that measure how extensive vitiligo is: a clinician-assessed extent score and a patient self-assessment score. This international study identified the threshold of change in these scores at which patients feel they have 'truly improved.'
J Am Acad Dermatol (2021)
NO. 47
In vitiligo patients who received long-term narrowband UVB phototherapy, major fractures due to osteoporosis were less common. This suggests that phototherapy may have helped bones by producing vitamin D.
J Am Acad Dermatol (2021)
NO. 46
Taking antioxidant supplements while undergoing phototherapy may be helpful. We have summarized the evidence by collecting the most reliable randomized controlled trials.
J Am Acad Dermatol (2021)
NO. 45
A total of 25,694 vitiligo patients were followed for a long time. Even with long-term use of Protopic ointment and ELIDEL cream along with long-term phototherapy, there was no increase in lymphoma or skin cancer.
J Am Acad Dermatol (2021)
NO. 44
Segmental vitiligo, which appears as a band on one side, was categorized by the shape of its occurrence on the face and trunk, and recurrences after treatment were summarized.
Br J Dermatol (2021)
NO. 43
We have gathered all the data from 117 vitiligo surgery studies and 8,776 patients published worldwide, without missing a single one. In stable vitiligo that does not improve with light therapy, repigmentation of more than half occurred in 81% of cases after surgery.
JAMA Dermatol (2021)
NO. 42
For 12 vitiligo treatment issues where opinions among doctors varied due to lack of evidence, 31 domestic vitiligo experts gathered and reached a consensus to provide answers.
Photodermatol Photoimmunol Photomed (2021)
NO. 41
In vitiligo patients who received more than 100 sessions of phototherapy over a long period, the risk of developing conditions such as myocardial infarction or stroke was about 36% lower.
J Eur Acad Dermatol Venereol (2021)
NO. 40
Vitiligo experts from around the world gathered to establish a standard method for taking photos, ensuring they can be compared regardless of when or where they are taken.
J Am Acad Dermatol (2020)
NO. 39
We compared excimer laser applied with enough energy to cause the skin to turn red versus excimer laser applied gently enough not to cause redness. In both cases, Protopic ointment was also applied. This trial aimed to find a balance between safety and effectiveness.
J Am Acad Dermatol (2020)
NO. 38
Vitiligo patients and their families actively shared hospital recommendations, diagnosis and treatment inquiries, and personal thoughts in online communities. This is the result of our research team's analysis of 1,000 Naver Cafe posts.
Korean J Dermatol (2020)
NO. 37
Using a special ultraviolet lamp (365 nm Wood's lamp), even pale vitiligo lesions that are easily missed with the naked eye can be seen clearly.
J Am Acad Dermatol (2020)
NO. 36
Making the skin grafts as small as 0.5 mm had many advantages. Scarring was minimal, many could be densely placed, and recovery was fast. Moreover, because they were so small, even when placed like seeding without matching the top and bottom direction, color returned equally well.
J Dermatol (2020)
NO. 35
When vitiligo lesions were photographed with a special ultraviolet camera, the image quality was much better than with a regular camera. Measuring lesion size was also accurate and consistent.
J Eur Acad Dermatol Venereol (2020)
NO. 34
We added micro-punch grafting as an auxiliary method to areas where cell transplantation was not effective. This method to increase the possibility of color return was introduced.
J Am Acad Dermatol (2020)
NO. 33
Using only a smartphone and a simple polarizing film, glare on the skin surface can be eliminated. We introduced a method to photograph vitiligo white patches and other skin lesions more clearly.
J Am Acad Dermatol (2020)
NO. 32
Even after receiving hundreds of phototherapy sessions, the risk of skin cancer did not increase. However, exceeding 200 sessions may slightly increase the risk of actinic keratosis, a precancerous condition, so it is advisable to monitor the skin.
JAMA Dermatol (2020)
NO. 31
Micro-tattooing (medical tattooing) was performed for vitiligo that did not improve with excimer laser or phototherapy. In 8 out of 10 sites, the color matched the surrounding skin well.
J Dermatol (2020)
NO. 30
Micropigmentation (medical tattooing) was performed for vitiligo on areas like the hands and feet where treatment is not very effective. Among 20 lesions, color matched the surrounding skin in 17—more than eight out of ten.
Korean J Dermatol (2020)
NO. 29
Nevus depigmentosus is a congenital white spot, while segmental vitiligo is a disease where pigment cells disappear and can spread. The 'stamp test,' where an excimer laser is lightly applied like a stamp, can differentiate the two without difficulty.
Pigment Cell Melanoma Res (2019)
NO. 28
Even after long-term excimer laser treatment, the risk of skin cancer did not increase in vitiligo patients. This safety finding was confirmed by analyzing data from over 5,000 Korean patients.
Pigment Cell Melanoma Res (2019)
NO. 27
Protopic ointment and ELIDEL cream showed considerable effectiveness for vitiligo even when used alone. When combined with light therapy, the effectiveness increased further. They are a good option for those who are concerned about using steroids.
JAMA Dermatol (2019)
NO. 26
Having vitiligo was associated with a lower risk of cancers developing in internal organs. This finding was confirmed by examining over 100,000 patients in Korea.
J Clin Oncol (2019)
NO. 25
The newer PALLAS laser was as effective and safe as the current standard excimer laser. This adds one more treatment option for vitiligo.
Lasers Surg Med (2019)
NO. 24
VESTA is an assessment tool designed to accurately measure how much color has returned after treatment. When used by specialists, it proved more accurate and consistent than visual estimation.
Pigment Cell Melanoma Res (2019)
NO. 23
This is a case of vitiligo developing on a keloid scar. It is an example of the Koebner phenomenon, where the disease appears on irritated skin, and shows why it is important to reduce unnecessary skin irritation in vitiligo.
J Dermatol (2019)
NO. 22
This is a case of segmental vitiligo appearing along the lines of embryonic skin development (Blaschko lines). It suggests that this condition may be related to the early distribution of pigment cells.
Ann Dermatol (2018)
NO. 21
Pregnant women with vitiligo had a slightly higher rate of miscarriage and a somewhat lower rate of full-term delivery. However, the difference was not large enough to cause significant concern.
J Am Acad Dermatol (2018)
NO. 20
This is a case of contact vitiligo where white patches appeared on the skin touched by the rubber ear loops of disposable masks. Certain chemicals in the rubber can damage pigment cells.
Eur J Dermatol (2018)
NO. 19
In refractory vitiligo that did not improve with excimer laser or phototherapy, motorized 0.8 mm micro-punch grafting restored color in about eight out of ten cases. It is a fast and simple surgical alternative.
J Am Acad Dermatol (2018)
NO. 18
This is a case of a 14-year-old girl who developed vitiligo on her legs after a bone marrow transplant (hematopoietic stem cell transplant) for acute leukemia. She was safely treated with epidermal cell grafting from suction blisters, and her skin color was restored.
Korean J Dermatol (2018)
NO. 17
Facial vitiligo was classified into three types based on the location of the lesions: centrofacial, generalized facial, and hairline-limited. The age of onset and treatment response differed by type.
Pigment Cell Melanoma Res (2018)
NO. 16
With non-cultured epidermal cell suspension, which transfers epidermal cells from a small blister skin to a large vitiligo area, over 75% repigmentation was achieved in 85% of 20 cases.
Korean J Dermatol (2018)
NO. 15
This is a case where applying DuoDERM over Protopic caused a mild irritation, after which color returned to the vitiligo patches faster than expected.
Eur J Dermatol (2018)
NO. 14
People who received anti-TNF biologic injections for ankylosing spondylitis, Crohn's disease, or ulcerative colitis had about twice the risk of developing vitiligo.
J Invest Dermatol (2018)
NO. 13
This clinical trial examined whether an 'intermittent' regimen of excimer laser (with breaks) is not significantly inferior to a 'continuous' regimen (without breaks).
J Am Acad Dermatol (2018)
NO. 12
New-onset vitiligo was less common in people taking immunosuppressants after organ transplantation. This supports the understanding that vitiligo is an immune-related condition.
J Am Acad Dermatol (2018)
NO. 11
Vitiligo had a greater negative impact on quality of life when it was on visible areas or covered a larger area. This was confirmed by a survey of 1,123 patients from 21 hospitals nationwide.
Br J Dermatol (2018)
NO. 10
This is a pilot study that first examined the efficacy and safety of a newly attempted PALLAS laser (311nm) for vitiligo treatment in 14 patients.
JAMA Dermatol (2017)
NO. 09
This is a case where dormant herpes simplex virus was reactivated after excimer laser treatment for vitiligo. It is a rare but noteworthy side effect.
Ann Dermatol (2017)
NO. 08
People with vitiligo had a higher risk of also having lupus, systemic sclerosis, Sjögren's syndrome, and rheumatoid arthritis.
J Dermatol (2017)
NO. 07
Longer phototherapy led to greater color restoration, and the response was most favorable on the face and neck. Hands and feet showed little response. These results are from phototherapy alone, without adding other treatments.
JAMA Dermatol (2017)
NO. 06
Autoimmune thyroid diseases such as Graves' disease and Hashimoto's thyroiditis were significantly more common in people with vitiligo. Thyroid cancer was also slightly more common.
J Am Acad Dermatol (2017)
NO. 05
Converting photographs taken under a Wood's lamp to high-contrast black-and-white makes subtle vitiligo lesions and their borders much more distinct.
J Am Acad Dermatol (2017)
NO. 04
People who received a hematopoietic stem cell transplant were about three times more likely to develop new-onset vitiligo than those who did not. The risk was especially higher with allogeneic transplants and when cells from bone marrow were used.
J Am Acad Dermatol (2017)
NO. 03
White hair in vitiligo patches usually does not regain its color. However, in very rare cases, color has returned. We report the course of one such patient.
J Am Acad Dermatol (2016)
NO. 02
Adding Protopic ointment or ELIDEL cream to excimer laser treatment led to greater improvement in vitiligo compared to laser alone. In contrast, evidence for adding vitamin D ointment or steroids was insufficient.
J Am Acad Dermatol (2016)
NO. 01
Three treatments were used together in 159 patients with segmental vitiligo. More than half (50.3%) achieved 75% or greater repigmentation.
J Am Acad Dermatol (2015)
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